The Best Disinfectant Sprays

Keeping your home clean and germ-free is more important now than ever, and with all of the options available, it can be hard to find the best disinfectant spray. You want to look for one that will kill a variety of bacteria, viruses, and other nasty germs while also being safe for your children and pets to be around. How do you know which one to buy when faced with so many choices?

We took a look at many different brands and types of disinfectant sprays in an effort to bring you the best ones. Below, you’ll find our top five, separated into various categories. We looked at a variety of features, including how well the disinfectants work, how they smell, the ingredients listed, and how Amazon reviewers felt about them.

All the products mentioned below can be purchased from the comfort of your own home on Amazon and delivered to your door. No need to go out!

Best Disinfectant Spray Overall
Lysol All-Purpose Cleaner
This lemon-scented classic keeps your home clean and 99% germ-free.

Our top pick goes to Lysol All-Purpose Cleaner. This is a popular brand, and for good reason. It kills 99 percent of bacteria, viruses, and other germs. It also smells good and cuts through grime easily. This is a lemon fragrance, but Lysol has various scents available, so pick your favorite. If you’re looking for a deep-down clean with a well-known brand, this is one you’ll want to check out.

The 5 Top-Rated Disinfectant Sprays

Editor's PicksBrandRating
Best OverallLysol All-Purpose Cleaner4.9
Best Natural SprayPureGreen244.7
Best Budget BuyFabuloso All Purpose Cleaner4.9
Best With BleachClorox Clean-Up4.8
Best With VinegarAunt Fannie’s Cleaning Vinegar4.4

*Ratings are from Amazon and may change over time.

Best Disinfectant Spray Overall: Lysol All-Purpose Cleaner

Best Disinfectant Spray Overall
Lysol All-Purpose Cleaner
This lemon-scented classic keeps your home clean and 99% germ-free.

Lysol All-Purpose Cleaner came out heads and shoulders above the rest when it came to choosing the best disinfectant spray. You probably recognize the brand, because it’s one of the most common names out there among household cleaners. This one is lemon-scented, but there are a lot of scents to choose from, including fruity and floral fragrances, so you’re sure to find one that smells wonderful to you.

Lysol All-Purpose Cleaner kills 99 percent of germs, so you can feel secure using it in your kitchen, bathroom, and ever other room in your home. Go ahead and spray it on the kitchen counters after preparing raw chicken and know that it will take care of the germs. Other popular uses are to spray down the toilets and to use it on a paper towel or rag for high-touch areas such as light switches and doorknobs.

This product is also great for cutting grease and grime. Try it on your stove after cooking spaghetti sauce or to mop up dog footprints off of your tile or linoleum floor. At the same time, it isn’t as caustic as bleach. Always wash your hands after use and be careful not to get it in your eyes or on your clothing.

Lysol All-Purpose Cleaner Key Features:

  • Kills more than 99% of bacteria and viruses
  • Comes in various scents
  • Easy-to-use spray bottle
  • Eliminates grease, grime, and soap scum
  • Good to use in kitchens and bathrooms
  • Wash hands after use

Best Natural Disinfectant Spray: PureGreen24

Best Natural Disinfectant Spray
This spray kills germs without toxic, dangerous chemicals.

If you are looking for a natural disinfectant spray, our favorite is PureGreen24. It is safe and non-toxic, but strong enough to kill influenza, staph, MRSA, and NoroVirus germs. It is gentle enough to use on children’s toys and doesn’t need to be rinsed before they play with them again. This spray also offers 24-hour residual protection, so you can feel secure that your counters, bathrooms, and high-touch areas will remain protected from additional contamination (though you should always re-clean if anything looks visibly dirty or if you know it has become re-contaminated).

PureGreen24 is odorless and it is safe for use around pets. It can be used in places like restaurants, offices, hotels, veterinary clinics, and medical offices, so rest assured that it is effective enough to use in your home. None of the chemicals in the product are listed as harmful according to the EPA. You do need to wipe it after use, particularly if you are using it on floors, because it will leave a sticky residue if left to dry without being wiped.

PureGreen24 Key Features:

  • Non-toxic
  • Safe to use around pets and children
  • Kills viruses and bacteria
  • Does not need to be rinsed
  • Offers 24-hour residual protection
  • Safe according to the EPA

Best Budget Disinfectant Spray: Fabuloso All Purpose Cleaner

Best Budget Disinfectant Spray
Fabuloso All Purpose Cleaner
Wallet-friendly spray that will leave your home smelling wonderful.

Are you looking for a budget-friendly option for a disinfectant spray? Try Fabuloso All Purpose Cleaner, which made our top spot among wallet-friendly sprays. This is an Amazon Pantry purchase, so on top of the low price, you’ll also get free shipping if you spend $35 in the Pantry. Note that this is a refill bottle; use it in an empty spray bottle or one that already contained Fabuloso. Do not use it in a bottle that contained any cleaner with bleach.

Fabuloso is a great all-purpose cleaner that can be used to clean and disinfect hard surfaces such as those found in the bathroom and kitchen. You can also dilute it and use it to mop the floors, giving your home a welcoming scent. This product comes in various fragrances; this one is the lavender scent. It can cut through grease and grime and will leave your home sparkling clean.

Fabuloso All Purpose Cleaner Key Features:

  • This is a refill bottle
  • Safe on non-porous surfaces
  • Can be used on windows
  • Comes in various fragrances
  • Can be diluted for some applications
  • Cuts through grease and grime
  • Free shipping through Amazon Pantry with minimum purchase

Best Spray Disinfectant With Bleach: Clorox Clean-Up

Best Spray Disinfectant With Bleach
Clorox Clean-Up
Use the power of bleach to kill germs all over your home.

Clorox Clean-Up is our top pick for disinfectants containing bleach. Bleach is often a favorite disinfectant not only in homes but also in hospitals, medical facilities, restaurants, and other places with a lot of human traffic. It kills viruses, bacteria, and other types of germs on contact. This is a refill bottle; you can use it to fill empty bottles that you purchased new or that previously contained Clorox Clean-Up. Do not mix it with other types of chemicals: For example, you should not use this refill to fill a bottle that once contained a different type of cleaner, as it can create harmful fumes. Depending on the reason you’re using it, you might want to dilute it with plain water. Read the directions on the bottle.

As with all products containing bleach, you will need to use caution with this product. Don’t use it on anything that might become discolored, such as fabric. You also shouldn’t use it if you are sensitive to bleach or if you have respiratory issues such as emphysema or asthma.

Use this bleach disinfectant spray to remove mildew and mold from hard surfaces in your home. You can also use it to clean bathrooms and kitchen surfaces and to mop tile and linoleum floors. Do not get it on your clothing or in your eyes.

Clorox Clean-Up Key Features:

  • Kills bacteria, viruses, and mold
  • Can be used in the home or in a commercial setting
  • This is a refill bottle
  • Do not mix with other cleaners
  • Do not use on fabrics or get on clothing
  • Do not get it in your eyes

Best Disinfectant Spray With Vinegar: Aunt Fannie’s Cleaning Vinegar

Best Disinfectant Spray With Vinegar
Aunt Fannie's Cleaning Vinegar
Use this cleaning vinegar to keep your home clean and fresh.

Many people like cleaning with vinegar, so we looked for the best disinfectant spray with vinegar and found Aunt Fannie’s Cleaning Vinegar to be the best. This is a non-toxic cleaning spray that is safe to use around children and pets, just like you would use the vinegar already in your cabinet. Vinegar is known to be a good general household cleaner and is often used as a natural alternative to harsher chemicals. It also helps eliminate dirt, grime, and grease and is a great rinsing agent to keep surfaces squeaky clean and spot-free.

Aunt Fannie’s Cleaning Vinegar also contains essential oils, which cut through the vinegar smell, making it a great option for those who don’t like the odor of vinegar. This one contains eucalyptus oil, and there are other fragrances available as well. Use it in your bathrooms, kitchen, and other areas of the home. You can even use it in the playroom and in kids’ bedrooms without concern.

Aunt Fannie’s Cleaning Vinegar Key Features:

  • Non-toxic cleaning spray
  • Contains eucalyptus oil
  • Can be used on hard surfaces
  • Safe to be used around children and pets
  • Smells good

Keeping your family safe and healthy can be a big job, but with the help of one of the disinfectant sprays we’ve reviewed, it will be that much easier. If you’re wondering how you can best keep your floors clean, you’ll want to check out our list of the best mops.